La risposta delle cellule T nella diagnosi della malattia di Lyme – paolomaccallini

“In questi giorni è stato pubblicato dalla prestigiosa rivista Clinical Infectious Diseases uno studio su un test di stimolazione delle cellule T nella diagnosi della Lyme precoce (Early Lyme) (Callister, SM et al. 2016). Sebbene numerosi studi su metodologie analoghe siano stati prodotti fin dalla scoperta dell’agente eziologico della malattia di Lyme, questa pubblicazione sembra il segno di una apertura verso il riconoscimento di tale metodica diagnostica. […]”

https://paolomaccallini.wordpress.com/2016/05/08/first-blog-post/

The Lyme disease pathogen Borrelia burgdorferi infects murine bone and induces trabecular bone loss. – PubMed – NCBI

“Lyme disease is caused by members of the Borrelia burgdorferi sensu lato species complex. Arthritis is a well-known late-stage pathology of Lyme disease, but the effects of B. burgdorferi infection on bone at sites other than articular surfaces are largely unknown. In this study, we investigated whether B. burgdorferi infection affects bone health in mice. In mice inoculated with B. burgdorferi or vehicle (mock infection), we measured the presence of B. burgdorferi DNA in bones, bone mineral density (BMD), bone formation rates, biomechanical properties, cellular composition, and two- and three-dimensional features of bone microarchitecture. B. burgdorferi DNA was detected in bone. […]”

https://www.ncbi.nlm.nih.gov/m/pubmed/27956598/

Nuovi farmaci contro le forme persistenti di Borrelia burgdorferi – paolomaccallini

“Dopo una introduzione al fenomeno di persistenza batterica e al suo possibile ruolo nelle forme croniche della malattia di Lyme, passo in rassegna alcune ricerche recenti su nuove sostanze antibiotiche. […]”

https://paolomaccallini.wordpress.com/2016/11/25/nuovi-farmaci-persistenza/

Reaction of Monoclonal and Polyclonal Antibodies Made against Infectious Agents with Various Food Antigens | Open Access Journals

“During the past 10 years in our clinical immunology laboratory, we have observed that some patients with high titers of antibodies against the Herpes family of viruses also exhibit elevation in antibodies against Borrelia burgdorferi antigens. Furthermore, when sera from patients with high IgG antibody levels against B. burgdorferi and Epstein-Barr virus were tested for food-specific antibodies, the degree of immune reactivity to food antigens was much higher in patients who were seropositive for B. burgdorferi and EBV antigens than in those who were seronegative. We purchased monoclonal and affinity-purified polyclonal antibodies against B. burgdorferi, Herpes family viruses and other infectious agents, and reacted them with 180 different food antigens so we could examine the degree of cross-reactivity between infectious agents and various food antigens. […]”

 

http://www.omicsonline.org/open-access/reaction-of-monoclonal-and-polyclonal-antibodies-made-against-infectious-agents-with-various-food-antigens-2155-9899-1000359.php?aid=62890