“[…] Gli studi di Armstrong, Yamano e Naviaux sono ascrivibili a quella disciplina (detta metabolomica) che si occupa di effettuare misure metaboliche attraverso l’acquisizione contemporanea di decine, centinaia o migliaia di dati, dallo stesso campione biologico. Una di queste tecniche è la spettroscopia di massa, la quale misura la concentrazione – nel campione – di macromolecole opportunamente ionizzate e immesse in un campo elettromagnetico, e si basa in pratica sullo sfruttamento della seconda legge di Newton e della forza di Lorentz. […]”
“For years, of course, some researchers and doctors championed the idea that problems with mitochondrial energy production were at the heart of ME/CFS. For many, though, the idea seemed almost too simple…too easy in a way. The body throws too many curves at us for something so obvious to be the cause. But it may be. […]”
“Infections are frequently associated with chronic disease development and likely, play crucial roles in
the onset or progression of several human disorders that are not classified as infectious diseases.
Myalgic encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) is one such example. However, the
precise role of pathogens in ME/CFS development remains, predominantly, uncharacterized. Human
Herpesvirus 6 (HHV-6) is frequently associated with several human diseases including ME/CFS. Work
from my laboratory as well as from others have shown that HHV-6 frequently integrates into human
chromosomes in order to achieve latency (ciHHV-6). Originally, ciHHV-6 was thought to be the dead
end for the virus. However recent publications demonstrate that certain timely triggers like
circumstances of immune suppression or influence of various drugs and/or pathogenic infections can
activate the integrated virus. [..]”
“Systemic autoimmune diseases (SADs) are a group of connective tissue diseases with diverse, yet overlapping, symptoms and autoantibody development. The etiology behind SADs is not fully elucidated, but a number of genetic and environmental factors are known to influence the incidence of SADs. Recent findings link dysregulation of Epstein-Barr virus (EBV) with SAD development. EBV causes a persistent infection with a tight latency programme in memory B-cells, which enables evasion of the immune defence. A number of immune escape mechanisms and immune-modulating proteins have been described for EBV. […]”
“[…] esistono purtroppo patologie rare che non determinano menomazioni fisiche evidenti, ma rovinano la vita di chi ne è affetto e fra queste si possono citare: la Fibromialgia, la Sensibilità Chimica Multipla e l’Encefalite Mialgica, descritte in altrettanti articoli pubblicati su questo stesso blog negli ultimi dieci mesi.
Considerati spesso alla stregua di malati immaginari, coloro i quali ne soffrono, non solo vengono offesi in quanto pazienti, bensì come esseri umani, vedendo lesa la propria dignità sia in pubblico che in privato (evitando ovviamente generalizzazioni). […]”
“The first thing I asked him about was the expanded metabolomic ME/CFS study I’d just given blood for. Naviaux’s initial metabolomics study generated some big waves in the ME/CFS community. Subsequently Maureen Hanson’s and Fluge and Mellas’ studies found broadly similar findings. The Simmaron Research Foundation is using Naviaux’s results to inform their own enlarged spinal fluid study, and the Solve ME/CFS Initiative just funded a metabolic analysis of B-cells. Plus, in the wake of Naviaux’s study we took a new look at what turned out to be some earlier fascinating Australian metabolomics studies. Naviaux’s study opened up a new world for many of us.
Naviaux’s current study is about 50% bigger than the first and will contain roughly equal numbers of men and women. Naviaux will be analyzing his own mass spectrometer results, but in the second part of the study Oliver Fiehn at UC Davis will be implementing Naviaux’s methods on a different mass spectrometer machine. Fiehn’s West Coast Metabolomics Center is an NIH Regional Resource Core designed to advance the use of metabolomics in medical research and other fields. Fiehn is a well-published author who recently co-authored a metabolomics cerebral spinal fluid study which predicted the progression of Alzheimer’s with 99% accuracy.
The analysis for the expanded ME/CFS study should be done by July of next year with the paper published hopefully 4-5 months later. […]”
Il trattamento della fatica non può al momento giovarsi di un farmaco di elezione, in quanto non si sono dimostrati sicuri benefici “evidence-based” con nessuno dei farmaci finora testati. […]”
“A Central Nervous System Hypothesis of Chronic Fatigue Syndrome
“… neurophysiological and neuroimaging studies in combination with subjective or a newly developed objective evaluation method of chronic fatigue have begun to clarify the mechanisms underlying chronic cognitive fatigue …”
Deciding that ‘chronic fatigue’ had become not just an illness problem but a productivity concern for their economy, the Japanese initiated a program a couple of decades ago to understand and treat it. They note that a third of the Japanese population complains of “chronic fatigue” and that “chronic fatigue” contributes to cardiovascular conditions, epilepsy, and early death. Their program has encompassed all levels of fatigue from chronic fatigue to chronic fatigue syndrome. We’ve missed out on a lot of their work focused on fatigue because it doesn’t show up in searches for Chronic Fatigue Syndrome (ME/CFS). […]”
Tra le altre cose, mi è capitato di studiare un modello quantitativo per la riduzione del metabolismo di B. burgdorferi quando il battere è esposto a sostanze per lei tossiche, come la doxiciclina. Infatti è così che la spirocheta si difende e sopravvive alla doxiciclina: diminuisce il suo metabolismo (Sharma, B et al. 2015) e si gonfia, riducendo il rapporto superficie/volume di circa 6 volte (Maccallini, P).
Ebbene, ieri stavo riguardando la soluzione del sistema di equazioni che ho usato per descrivere la velocità del metabolismo di una colonia di spirochete, e ho capito. Quello che stavo osservando, tra il confuso e lo stupidamente compiaciuto, era il dauer di Naviaux, l’ipometabolismo dei mitocondri descritto da Robert Naviaux nel recente articolo sul metabolismo dei pazienti CFS! Più precisamente, avevo descritto l’ipometabolismo di B. burgdorferi, il dauer di questa spirocheta.
Quello che voglio dire è…
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“Fatigue is one of the most pervasive symptoms of multiple sclerosis (MS), and has engen- dered hundreds of investigations on the topic. While there is a growing literature using various methods to study fatigue, a unified theory of fatigue in MS is yet to emerge. In the current review, we synthesize findings from neuroimaging, pharmacological, neu- ropsychological, and immunological studies of fatigue in MS, which point to a specific hypothesis of fatigue in MS: the dopamine imbalance hypothesis. The communication between the striatum and prefrontal cortex is reliant on dopamine, a modulatory neu- rotransmitter. Neuroimaging findings suggest that fatigue results from the disruption of communication between these regions. Supporting the dopamine imbalance hypothesis, structural and functional neuroimaging studies show abnormalities in the frontal and striatal regions that are heavily innervated by dopamine neurons. Further, dopaminergic psychos- timulant medication has been shown to alleviate fatigue in individuals with traumatic brain injury, chronic fatigue syndrome, and in cancer patients, also indicating that dopamine might play an important role in fatigue perception. This paper reviews the structural and functional neuroimaging evidence as well as pharmacological studies that suggest that dopamine plays a critical role in the phenomenon of fatigue. We conclude with how specific aspects of the dopamine imbalance hypothesis can be tested in future. […]”