Test metabolomici – paolomaccallini

“[…] Gli studi di Armstrong, Yamano e Naviaux sono ascrivibili a quella disciplina (detta metabolomica) che si occupa di effettuare misure metaboliche attraverso l’acquisizione contemporanea di decine, centinaia o migliaia di dati, dallo stesso campione biologico. Una di queste tecniche è la spettroscopia di massa, la quale misura la concentrazione – nel campione – di macromolecole opportunamente ionizzate e immesse in un campo elettromagnetico, e si basa in pratica sullo sfruttamento della seconda legge di Newton e della forza di Lorentz. […]”


Fuel Shortage: Norwegian Study Expands on Energy Problem in Chronic Fatigue Syndrome (ME/CFS) – Health Rising

“For years, of course, some researchers and doctors championed the idea that problems with mitochondrial energy production were at the heart of ME/CFS. For many, though, the idea seemed almost too simple…too easy in a way. The body throws too many curves at us for something so obvious to be the cause. But it may be. […]”


HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS | Solve ME/CFS Initiative

“Infections are frequently associated with chronic disease development and likely, play crucial roles in
the onset or progression of several human disorders that are not classified as infectious diseases.
Myalgic encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) is one such example. However, the
precise role of pathogens in ME/CFS development remains, predominantly, uncharacterized. Human
Herpesvirus 6 (HHV-6) is frequently associated with several human diseases including ME/CFS. Work
from my laboratory as well as from others have shown that HHV-6 frequently integrates into human
chromosomes in order to achieve latency (ciHHV-6). Originally, ciHHV-6 was thought to be the dead
end for the virus. However recent publications demonstrate that certain timely triggers like
circumstances of immune suppression or influence of various drugs and/or pathogenic infections can
activate the integrated virus. [..]”


Epstein-Barr Virus in Systemic Autoimmune Diseases

“Systemic autoimmune diseases (SADs) are a group of connective tissue diseases with diverse, yet overlapping, symptoms and autoantibody development. The etiology behind SADs is not fully elucidated, but a number of genetic and environmental factors are known to influence the incidence of SADs. Recent findings link dysregulation of Epstein-Barr virus (EBV) with SAD development. EBV causes a persistent infection with a tight latency programme in memory B-cells, which enables evasion of the immune defence. A number of immune escape mechanisms and immune-modulating proteins have been described for EBV. […]”


Ampligen and hypometabolism

paolo maccallini


A few days ago Naviaux and colleagues have provided convincing proofs for the presence of an hypometabolic state in chronic fatigue syndrome (CFS) patients, with a pattern opposite to the one seen in response to acute infections. Naviaux et al. express the hypothesis that the metabolic shut down described in their paper “may represent a fundamental response to oppose the spread of persistent viral and intracellular bacterial infections” (Naviaux RK et al., 2016).

CFS is a condition without a definitive cure, although some pharmacological interventions have shown some efficacy in subgroups of patients. One of them is rintatolimod (brand name: Ampligen), a viral double stranded RNA (dsRNA) which selectively binds to toll like receptor 3 (TLR3), thus contributing to the induction of antiviral defenses (Gowen, BB et al., 2007). Approximately 30-40% of CFS/ME patients can be expected to respond beneficially to rintatolimod, according to the…

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