Test metabolomici – paolomaccallini

“[…] Gli studi di Armstrong, Yamano e Naviaux sono ascrivibili a quella disciplina (detta metabolomica) che si occupa di effettuare misure metaboliche attraverso l’acquisizione contemporanea di decine, centinaia o migliaia di dati, dallo stesso campione biologico. Una di queste tecniche è la spettroscopia di massa, la quale misura la concentrazione – nel campione – di macromolecole opportunamente ionizzate e immesse in un campo elettromagnetico, e si basa in pratica sullo sfruttamento della seconda legge di Newton e della forza di Lorentz. […]”


Fuel Shortage: Norwegian Study Expands on Energy Problem in Chronic Fatigue Syndrome (ME/CFS) – Health Rising

“For years, of course, some researchers and doctors championed the idea that problems with mitochondrial energy production were at the heart of ME/CFS. For many, though, the idea seemed almost too simple…too easy in a way. The body throws too many curves at us for something so obvious to be the cause. But it may be. […]”


HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS | Solve ME/CFS Initiative

“Infections are frequently associated with chronic disease development and likely, play crucial roles in
the onset or progression of several human disorders that are not classified as infectious diseases.
Myalgic encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) is one such example. However, the
precise role of pathogens in ME/CFS development remains, predominantly, uncharacterized. Human
Herpesvirus 6 (HHV-6) is frequently associated with several human diseases including ME/CFS. Work
from my laboratory as well as from others have shown that HHV-6 frequently integrates into human
chromosomes in order to achieve latency (ciHHV-6). Originally, ciHHV-6 was thought to be the dead
end for the virus. However recent publications demonstrate that certain timely triggers like
circumstances of immune suppression or influence of various drugs and/or pathogenic infections can
activate the integrated virus. [..]”


Epstein-Barr Virus in Systemic Autoimmune Diseases

“Systemic autoimmune diseases (SADs) are a group of connective tissue diseases with diverse, yet overlapping, symptoms and autoantibody development. The etiology behind SADs is not fully elucidated, but a number of genetic and environmental factors are known to influence the incidence of SADs. Recent findings link dysregulation of Epstein-Barr virus (EBV) with SAD development. EBV causes a persistent infection with a tight latency programme in memory B-cells, which enables evasion of the immune defence. A number of immune escape mechanisms and immune-modulating proteins have been described for EBV. […]”


La risposta delle cellule T nella diagnosi della malattia di Lyme – paolomaccallini

“In questi giorni è stato pubblicato dalla prestigiosa rivista Clinical Infectious Diseases uno studio su un test di stimolazione delle cellule T nella diagnosi della Lyme precoce (Early Lyme) (Callister, SM et al. 2016). Sebbene numerosi studi su metodologie analoghe siano stati prodotti fin dalla scoperta dell’agente eziologico della malattia di Lyme, questa pubblicazione sembra il segno di una apertura verso il riconoscimento di tale metodica diagnostica. […]”


Disabilità invisibili: quando l’ignoranza ferisce prima di uccidere – Linkiesta.it

“[…] esistono purtroppo patologie rare che non determinano menomazioni fisiche evidenti, ma rovinano la vita di chi ne è affetto e fra queste si possono citare: la Fibromialgia, la Sensibilità Chimica Multipla e l’Encefalite Mialgica, descritte in altrettanti articoli pubblicati su questo stesso blog negli ultimi dieci mesi.

Considerati spesso alla stregua di malati immaginari, coloro i quali ne soffrono, non solo vengono offesi in quanto pazienti, bensì come esseri umani, vedendo lesa la propria dignità sia in pubblico che in privato (evitando ovviamente generalizzazioni). […]”


Dr. Byron Hyde – paolomaccallini

“In questa playlist ho raccolto una serie di brevi interviste al dr. Byron Hyde, un medico canadese che si occupa di ME/CFS da molti anni, il quale ha sviluppato una teoria secondo la quale la ME sarebbe una infezione del cervello da parte di un enterovirus. […]”


Can patients with chronic fatigue syndrome really recover after graded exercise or cognitive behavioural therapy? A critical commentary and preliminary re-analysis of the PACE trial: Fatigue: Biomedicine, Health & Behavior: Vol 0, No 0

“The claim that patients can recover as a result of CBT and GET is not justified by the data, and is highly misleading to clinicians and patients considering these treatments. […]”


Recovery Potentially Possible: Naviaux Talks on Chronic Fatigue Syndrome (ME/CFS) – Health Rising

“The first thing I asked him about was the expanded metabolomic ME/CFS study I’d just given blood for. Naviaux’s initial metabolomics study generated some big waves in the ME/CFS community. Subsequently Maureen Hanson’s and Fluge and Mellas’ studies found broadly similar findings. The Simmaron Research Foundation is using Naviaux’s results to inform their own enlarged spinal fluid study, and the Solve ME/CFS Initiative just funded a metabolic analysis of B-cells. Plus, in the wake of Naviaux’s study we took a new look at what turned out to be some earlier fascinating Australian metabolomics studies. Naviaux’s study opened up a new world for many of us.
Naviaux’s current study is about 50% bigger than the first and will contain roughly equal numbers of men and women. Naviaux will be analyzing his own mass spectrometer results, but in the second part of the study Oliver Fiehn at UC Davis will be implementing Naviaux’s methods on a different mass spectrometer machine. Fiehn’s West Coast Metabolomics Center is an NIH Regional Resource Core designed to advance the use of metabolomics in medical research and other fields. Fiehn is a well-published author who recently co-authored a metabolomics cerebral spinal fluid study which predicted the progression of Alzheimer’s with 99% accuracy.
The analysis for the expanded ME/CFS study should be done by July of next year with the paper published hopefully 4-5 months later. […]”


Dysfunction Junction: The ANS and CFS | Solve ME/CFS Initiative

“Autonomic nervous system (ANS) dysfunction is a common feature of CFS, and can cause symptoms in virtually every organ system. Circulatory symptoms include lightheadedness, cold hands and feet and palpitations or “anxiety.” In the digestive system, autonomic dysfunction can cause nausea, cramps, constipation, diarrhea and bloating. Autonomic dysfunction can also cause abnormal breathing and urinary patterns, and problems with balance and even vision. […]”