Fuel Shortage: Norwegian Study Expands on Energy Problem in Chronic Fatigue Syndrome (ME/CFS) – Health Rising

“For years, of course, some researchers and doctors championed the idea that problems with mitochondrial energy production were at the heart of ME/CFS. For many, though, the idea seemed almost too simple…too easy in a way. The body throws too many curves at us for something so obvious to be the cause. But it may be. […]”


HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS | Solve ME/CFS Initiative

“Infections are frequently associated with chronic disease development and likely, play crucial roles in
the onset or progression of several human disorders that are not classified as infectious diseases.
Myalgic encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) is one such example. However, the
precise role of pathogens in ME/CFS development remains, predominantly, uncharacterized. Human
Herpesvirus 6 (HHV-6) is frequently associated with several human diseases including ME/CFS. Work
from my laboratory as well as from others have shown that HHV-6 frequently integrates into human
chromosomes in order to achieve latency (ciHHV-6). Originally, ciHHV-6 was thought to be the dead
end for the virus. However recent publications demonstrate that certain timely triggers like
circumstances of immune suppression or influence of various drugs and/or pathogenic infections can
activate the integrated virus. [..]”


Disabilità invisibili: quando l’ignoranza ferisce prima di uccidere – Linkiesta.it

“[…] esistono purtroppo patologie rare che non determinano menomazioni fisiche evidenti, ma rovinano la vita di chi ne è affetto e fra queste si possono citare: la Fibromialgia, la Sensibilità Chimica Multipla e l’Encefalite Mialgica, descritte in altrettanti articoli pubblicati su questo stesso blog negli ultimi dieci mesi.

Considerati spesso alla stregua di malati immaginari, coloro i quali ne soffrono, non solo vengono offesi in quanto pazienti, bensì come esseri umani, vedendo lesa la propria dignità sia in pubblico che in privato (evitando ovviamente generalizzazioni). […]”


Recovery Potentially Possible: Naviaux Talks on Chronic Fatigue Syndrome (ME/CFS) – Health Rising

“The first thing I asked him about was the expanded metabolomic ME/CFS study I’d just given blood for. Naviaux’s initial metabolomics study generated some big waves in the ME/CFS community. Subsequently Maureen Hanson’s and Fluge and Mellas’ studies found broadly similar findings. The Simmaron Research Foundation is using Naviaux’s results to inform their own enlarged spinal fluid study, and the Solve ME/CFS Initiative just funded a metabolic analysis of B-cells. Plus, in the wake of Naviaux’s study we took a new look at what turned out to be some earlier fascinating Australian metabolomics studies. Naviaux’s study opened up a new world for many of us.
Naviaux’s current study is about 50% bigger than the first and will contain roughly equal numbers of men and women. Naviaux will be analyzing his own mass spectrometer results, but in the second part of the study Oliver Fiehn at UC Davis will be implementing Naviaux’s methods on a different mass spectrometer machine. Fiehn’s West Coast Metabolomics Center is an NIH Regional Resource Core designed to advance the use of metabolomics in medical research and other fields. Fiehn is a well-published author who recently co-authored a metabolomics cerebral spinal fluid study which predicted the progression of Alzheimer’s with 99% accuracy.
The analysis for the expanded ME/CFS study should be done by July of next year with the paper published hopefully 4-5 months later. […]”


“They supported the idea that ‘sickness behavior’ is largely due to the immune system’s response to the pathogen, not the pathogen itself. Sickness behavior is the process whereby central nervous system processes induce feelings of fatigue, fever, and other flu-like sensations to stop an infected person from moving and cause them to take to bed, and thereby stop transmitting the pathogen to others in the community.”

Unrewarding Reward: The Basal Ganglia, Inflammation and Fatigue In Chronic Fatigue Syndrome – Health Rising


La nemesi e l’umbratile custode

paolo maccallini

Tra le altre cose, mi è capitato di studiare un modello quantitativo per la riduzione del metabolismo di B. burgdorferi quando il battere è esposto a sostanze per lei tossiche, come la doxiciclina. Infatti è così che la spirocheta si difende e sopravvive alla doxiciclina: diminuisce il suo metabolismo (Sharma, B et al. 2015) e si gonfia, riducendo il rapporto superficie/volume di circa 6 volte (Maccallini, P).

Ebbene, ieri stavo riguardando la soluzione del sistema di equazioni che ho usato per descrivere la velocità del metabolismo di una colonia di spirochete, e ho capito. Quello che stavo osservando, tra il confuso e lo stupidamente compiaciuto, era il dauer di Naviaux, l’ipometabolismo dei mitocondri descritto da Robert Naviaux nel recente articolo sul metabolismo dei pazienti CFS! Più precisamente, avevo descritto l’ipometabolismo di B. burgdorferi, il dauer di questa spirocheta.

Quello che voglio dire è…

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