HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS | Solve ME/CFS Initiative

“Infections are frequently associated with chronic disease development and likely, play crucial roles in
the onset or progression of several human disorders that are not classified as infectious diseases.
Myalgic encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) is one such example. However, the
precise role of pathogens in ME/CFS development remains, predominantly, uncharacterized. Human
Herpesvirus 6 (HHV-6) is frequently associated with several human diseases including ME/CFS. Work
from my laboratory as well as from others have shown that HHV-6 frequently integrates into human
chromosomes in order to achieve latency (ciHHV-6). Originally, ciHHV-6 was thought to be the dead
end for the virus. However recent publications demonstrate that certain timely triggers like
circumstances of immune suppression or influence of various drugs and/or pathogenic infections can
activate the integrated virus. [..]”

http://solvecfs.org/hhv-6-mediated-mitochondrial-modulation-and-its-possible-association-to-mecfs/

RNasi-L nella ME/CFS

paolo maccallini

In seguito a un attacco virale, le cellule del nostro corpo sintetizzano INF-alpha, una molecola che innesca la risposta antivirale del sistema immunitario innato, attivando le cellule NK (Sompayrac, How the immune system works, 2012). L’INF-alpha è anche coinvolto nell’attivazione dell’enzima 2-5A sintetasi, il quale a sua volta attiva l’enzima Rnasi-L. Quest’ultimo, tra le innumerevoli funzioni, è ritenuto costituire un attore importante della risposta antivirale (Englebienne e De Meirleir, Chronic fatigue syndrome, a biological approach, 2002). Ebbene, nella ME/CFS è stato dimostrata la presenza di una variante a basso peso molecolare di Rnasi-L (solo 37kD di peso), diversa da quella presente nel controllo sano (83kD di peso), la quale è stata associata a una disfunzione di questo ramo della risposta antivirale (Suhadolnik et al., 1997). Kenny De Meirleir sarebbe anche stato in grado di dimostrare che questa anomalia viene corretta dalla somministrazione dell’Ampligen nel…

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Epstein-Barr Virus and Hashimoto’s | Thyroid Pharmacist

“When I was taking my pharmacy licensing exam after graduation, I remember thinking that I could never possibly know more than I did at that time, but I have learned so much more since then- learning is one of my biggest passions- and I’ve found that the more I learn, the more I want to learn. I’m proud to say that I’ve now been a pharmacist for ten years- I graduated from pharmacy school in 2006. I hope to spend the next ten years learning even more! […]”

http://thyroidpharmacist.com/articles/epstein-barr-virus-and-hashimotos

“They supported the idea that ‘sickness behavior’ is largely due to the immune system’s response to the pathogen, not the pathogen itself. Sickness behavior is the process whereby central nervous system processes induce feelings of fatigue, fever, and other flu-like sensations to stop an infected person from moving and cause them to take to bed, and thereby stop transmitting the pathogen to others in the community.”

Unrewarding Reward: The Basal Ganglia, Inflammation and Fatigue In Chronic Fatigue Syndrome – Health Rising

http://www.healthrising.org/blog/2014/09/15/unrewarding-reward-basal-ganglia-inflammation-fatigue-chronic-fatigue-syndrome/

Reaction of Monoclonal and Polyclonal Antibodies Made against Infectious Agents with Various Food Antigens | Open Access Journals

“During the past 10 years in our clinical immunology laboratory, we have observed that some patients with high titers of antibodies against the Herpes family of viruses also exhibit elevation in antibodies against Borrelia burgdorferi antigens. Furthermore, when sera from patients with high IgG antibody levels against B. burgdorferi and Epstein-Barr virus were tested for food-specific antibodies, the degree of immune reactivity to food antigens was much higher in patients who were seropositive for B. burgdorferi and EBV antigens than in those who were seronegative. We purchased monoclonal and affinity-purified polyclonal antibodies against B. burgdorferi, Herpes family viruses and other infectious agents, and reacted them with 180 different food antigens so we could examine the degree of cross-reactivity between infectious agents and various food antigens. […]”

 

http://www.omicsonline.org/open-access/reaction-of-monoclonal-and-polyclonal-antibodies-made-against-infectious-agents-with-various-food-antigens-2155-9899-1000359.php?aid=62890